From the outer reaches of space to the small-town streets of suburbia, the hunt comes home. Now, the universe's most lethal hunters are stronger, smarter and deadlier than ever before, having genetically upgraded themselves with DNA from other species. When a young boy accidentally triggers their return to Earth, only a ragtag crew of ex-soldiers and a disgruntled science teacher can prevent the end of the human race.

A flamboyant English teacher (Clive Owen) and a new, stoic art teacher (Juliette Binoche) collide at an upscale prep school. A high-spirited courtship begins and she finds herself enjoying the battle. Another battle they begin has the students trying to prove which is more powerful, the word or the picture. But the true war is against their own demons, as two troubled souls struggle for connection.